Semaglutide Weight Loss

1. Clinical Trials: Clinical trials have demonstrated the effectiveness of Semaglutide for weight loss. In one study called the STEP (Semaglutide Treatment Effect in People with Obesity) trial, participants who received Semaglutide injections alongside lifestyle interventions experienced significant weight loss compared to those who received a placebo. The weight loss achieved using Semaglutide was often substantial, with many participants achieving clinically meaningful reductions in body weight.
2. Risks and Side Effects: Semaglutide carries potential risks and side effects. Common side effects may include nausea, vomiting, diarrhea, constipation, abdominal pain, and decreased appetite. These side effects are mild to moderate and tend to improve over time as the body adjusts to the medication. However, some individuals may experience severe gastrointestinal side effects.
3. Other Considerations: Semaglutide is typically administered by injection once a week or once daily, depending on the dosage and formulation. Individuals considering Semaglutide for weight loss need to discuss the potential benefits and risks with their healthcare provider. Semaglutide may not be suitable for everyone, and healthcare providers must assess each individual’s medical history and overall health before prescribing this medication.
4. Benefits Beyond Weight Loss: Semaglutide has other potential benefits, particularly in individuals with type 2 diabetes. It helps improve blood sugar, reduce the risk of cardiovascular events, and lower blood pressure. These benefits make Semaglutide a valuable treatment option for managing both diabetes and obesity, especially in individuals who struggle to achieve weight loss through diet and exercise alone.

Semaglutide, like any medication, has specific contraindications, which are situations where the use of the drug is not advisable due to potential risks or complications. Here are some common contraindications for Semaglutide:

1. Personal or Family History of Medullary Thyroid Carcinoma (MTC): Semaglutide is contraindicated in individuals with a personal or family history of MTC or in those with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). This is because GLP-1 receptor agonists, including Semaglutide, have been associated with an increased risk of MTC in animal studies.
2. Known Hypersensitivity to Semaglutide or its Components: Individuals who have had a hypersensitivity reaction to Semaglutide or any of its ingredients should not use this medication.
3. Severe Gastrointestinal Disease: Semaglutide can cause gastrointestinal side effects such as nausea, vomiting, and diarrhea. Therefore, it may not be suitable for individuals with severe gastrointestinal diseases or disorders.
4. End-Stage Renal Disease: Semaglutide is not recommended for use in individuals with end-stage renal disease (ESRD) or severe renal impairment (creatinine clearance less than 30 mL/min) due to limited data on its safety and efficacy in this population.
5. History of Diabetic Ketoacidosis (DKA): Semaglutide should be used cautiously in individuals with a history of DKA, as it may increase the risk of recurrence.
6. Pregnancy and Breastfeeding: The safety of Semaglutide during pregnancy and breastfeeding has not been established, and therefore, it is generally not recommended for use in these populations.
7. Liver Disease: Semaglutide should be used with caution in individuals with liver disease, as there is limited data on its safety and efficacy in this population.

It’s crucial for healthcare providers to thoroughly assess a patient’s medical history and current health status before prescribing Semaglutide to ensure that the potential benefits outweigh the risks. Additionally, individuals should inform their healthcare provider about any medical conditions they have and any medications they are currently taking to avoid possible drug interactions or complications.

Disclaimer: At Suvita Medical Aesthetics, we are NOT prescribing the Brand name Semaglutide, but we are prescribing the generic compounded (Semaglutide) injection, which is an injectable prescription medicine that is used for adults with obesity (BMI ≥30) or overweight (excess weight) (BMI ≥27) who have weight-related medical problems to help them lose weight and keep the weight off. 

When considering compounded Semaglutide for weight loss, it’s important to note that compounded medications, including Semaglutide, are prepared by pharmacies according to specific formulations tailored to individual patient needs. However, there are some important disclaimers and considerations to keep in mind:

1. Regulatory Approval: Compounded Semaglutide preparations for weight loss are not FDA-approved. The FDA currently approves semaglutide for the treatment of type 2 diabetes, but its use for weight loss is considered off-label. Compounded medications are not subjected to the same rigorous testing and regulatory oversight as FDA-approved drugs.
2. Safety and Efficacy: The safety and efficacy of compounded Semaglutide formulations for weight loss have not been established through large-scale clinical trials. While there may be anecdotal evidence or small-scale studies suggesting potential benefits, there is limited scientific data to support its use for weight loss outside of its approved indication for diabetes.
3. Risks and Side Effects: Compounded medications may carry risks similar to commercially available formulations, including potential side effects and adverse reactions. Individuals considering the use of compounded Semaglutide for weight loss should be aware of the possible risks, including gastrointestinal side effects, hypoglycemia (low blood sugar), and other complications.
4. Individualized Approach: Compounded medications are often prescribed individually, taking into account a patient’s unique medical history, health status, and treatment goals. It’s essential for healthcare providers to assess patients thoroughly before prescribing compounded Semaglutide for weight loss and to monitor their response to the treatment closely.
5. Informed Consent: Patients should receive thorough information about the compounded Semaglutide formulation, including its off-label use for weight loss, potential risks and side effects, and alternatives. Informed consent must be obtained before initiating treatment.
6. Consultation with Healthcare Provider: Individuals considering compounded Semaglutide for weight loss must consult a qualified healthcare provider, such as a physician or endocrinologist, who can provide guidance based on their specific health needs and circumstances.

While compounded Semaglutide preparations may be available for weight loss, it’s essential for individuals to approach their use with caution and to discuss potential risks and benefits with a healthcare provider. Additionally, individuals should be informed about the off-label nature of this use and the lack of regulatory approval for weight loss.

Overall, Semaglutide shows promise as a treatment for weight loss, particularly for individuals with obesity or overweight who may benefit from additional support in achieving their weight loss goals. However, like any medication, weighing the potential benefits against the risks and discussing them with a healthcare provider before starting treatment is essential.

Here at Suvita, we are happy to offer this new service as a comprehensive weight loss program. Every patient is required to meet with our holistic registered dietician, Michele Peters, MS RDN, and IFNCP.

As a team, we want our patients to have the healthiest outcome with the tools we give them for future and immediate success. Optional labs and supplements may also be recommended if needed.